CBD popularity can be on the rise, and it’s in part due to the nature of CBD and the range of consumption methods available. Edibles and tinctures can have less of the stigma traditionally associated with joints.
When our products are taken orally, bioavailability can become compromised.
This doesn’t signify a lesser product; in fact, our CBD oil is among the most effective on the market. What we are referring to is just the way oil works with the human body.
Want to get the most out of them? Here are our suggestions.
Like THC oils, CBD resists absorption into the bloodstream because the human body is up to 60% water. Mixing oil and water is no easy task. It’s just basic science.
That same concept can be analogous to the way cannabinoids work in the body.
CBD and its family of compounds are fat-loving molecules and have to in aqueous cellular pathways. Which makes sense when you consider just how much of the human body is comprised of water.
So the idea is that when cannabis is consumed as an oil, the onset of effects can become delayed and bioavailability limited.
This is contrary to the idea that the oil, often coconut oil being the medium, is the correct dosing method.
Proper Dosing With CBD Oil
Dosage is the critical factor in achieving the most benefits and least adverse effects of cannabis.
Considering bioavailability, these are the measurements recommended:
- Appetite: 2.5 milligrams of THC by mouth with or without 1 mg of CBD for six weeks
- Chronic pain: 2.5-20 mg CBD by mouth for an average of 25 days
- Sleep disorders: 40-160 mg CBD by mouth.
CannLabs, the nation’s top full-service testing lab for cannabis products, has determined no regular lethal CBD dose. Consumers should read product inserts carefully to ensure they are taking the right amount of CBD and talk to their prescribing physician about any questions or concerns.
The First-Pass Effect
The first-pass effect is what limits oil-based cannabis extracts from reaching the bloodstream in large quantities. Orally, CBD is absorbed in the gastrointestinal tract and transported via the portal vein to the liver, where metabolized and made of use to the body.
Since cannabis oil is often taken orally, its efficacy can be hindered.
Are some cannabinoids more bioavailable than others?
Investigations into CBD have shown that the bioavailability of cannabinoids depends on the method of delivery.
How to Optimize Bioavailability?
Since the CBD market explosion, a slew of products has rushed onto the market. However, they might be the culprit in limiting bioavailability. The “first pass” through the liver is the mechanism we want to understand. With oral CBD, absorption can be slow, unpredictable, and highly variable.
Despite the absorption speed, oral administration lasts longer than smoking, eliminating the need for frequent dosing. Oral and topical methods also avoid irritation to the airways and the risk of malignancies associated with smoking or vaping.
By following dosage guidelines and understanding limited bioavailability via consumption methods, we hope you can make the most of all your CBD products.
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